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'Two and a Half Men' (CBS)

Premieres: Monday, Sept. 21 Expect to See: "He's a guy with very few tools in his tool belt," series creator Chuck Lorre says of Charlie ( Charlie Sheen) living with Chelsea (Jennifer Bini Taylor). "We will continue to see Jon Cryer slowly unravel and become more and more eccentric and maybe have his character medicated for the last couple of seasons." For Jake (Angus T. Jones), Lorre says, "Lucky for us, his problems get more interesting as he gets older. He's a petri dish of hormones." Related: CBS lays out a tight fall premiere schedule Zap2it's Fall TV PreviewCBS