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Karen Sisco, 'Out of Sight' and 'Karen Sisco,'

In both her movie and TV incarnations, U.S. Marshal Karen Sisco combined smart, sexy and tough in a way that made her incredibly appealing. "Out of Sight" is still Lopez's best movie role, and Gugino and "Karen Sisco" were among the more unfortunate casualties of the pre- "Desperate Housewives"/"Lost" era on ABC.
ABC/Universal Pictures
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