Joseph Gordon-Levitt builds on his successes in "(500) Days of Summer" and "Inception" via his intriguing teamwork with Seth Rogen in this comedy-drama, which writer Will Reiser based on his own bout with cancer.

Gordon-Levitt plays a patient whose girlfriend (Bryce Dallas Howard) proves less than a stand-by-your-man type, so he finds his biggest support in his unconventional best friend (Rogen, of course) and a novice therapist (Anna Kendrick, also superb). Anjelica Huston, Matt Frewer ("Max Headroom") and Philip Baker Hall also are in the noteworthy cast. DVD extras: "making-of" documentary; audio commentary by cast and crew; deleted scenes. *** (R: AS, P) (Also on Blu-ray and Movies on Demand)

Buy '50/50' on DVD.

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