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The Panama Canal turns 100 on Aug. 15. After a decade of construction, the Frank Gehry-designed BioMuseo (pictured) is expected to begin a soft opening in February. In Panama City's Casco Viejo neighborhood, the 50-room American Trade Hotel (www.acehotel.com) opened in late 2013 in a converted 1917 department store. The Tantalo Hotel (www.tantalohotel.com) opened in 2012 with a rooftop bar. The Waldorf Astoria Panama (www.waldorfastoriapanama.com) opened in 2013. Out in the countryside, the tour company Backroads (www.backroads.com) is offering its first Panamanian walking and hiking trip.