Ace Hotel, 20 W. 29th St., (646) 214-5750 or (212) 679-2222, http://www.acehotel.com, has a cavernous lobby jam-packed with the in crowd, Stumptown Coffee Roasters, the Breslin Bar & Restaurant (by the same people who created the Spotted Pig downtown) and a range of room styles (including the economy bunk-bed model). $209.
Courtyard by Marriott, 181 Varick St., (800) 321-2211, http://www.courtyardsoho.com, in a new 19-story tower, is like every other functional, pared-down Courtyard, except that it's on the edge of inviting, artistic Soho. $259.
Crosby Street Hotel, 79 Crosby St., (888) 559-5508, http://www.crosbystreethotel.com, an 86-room boutique with whimsical décor in the heart of Soho, brought to you by Firmdale, the same firm that created the Covent Garden and Charlotte Street hotels in London. $475.
Fashion 26, 152 W. 26th St., (212) 858-5888, http://www.f26nyc.com, a cheerfully stylish Garment District hotel in a new brick and glass tower with art from the nearby Fashion Institute of Technology and mini-cupcakes at the front desk. $199.
Holiday Inn Long Island City, 39-05 29th St., Long Island City, Queens; (888) 465-4329, http://www.holidayinn.com, straightforward accommodations in a new building with an indoor pool, a quick subway ride from Midtown. $114.
The James, 27 Grand St., (888) 526-3778, http://www.jameshotels.com, a small, sedate place slipped into the west side of Soho, with a rooftop pool, deck and bar. $375.
The Standard, 848 Washington St., (877) 550-4646, http://www.standardhotels.com, a Meatpacking District hot spot by André Balazs of the L.A. Standards, straddles High Line park and has rooms with big exhibitionistic windows. $266.