The 34-year-old actress ("E.T.: The Extra-Terrestrial," the "Charlie's Angels" films) has confirmed that she's being considered for "Eclipse," the third movie in the blockbuster teen vamp saga that launched with "Twilight" last year.
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"I'm one of the directors that is being talked about, which is great, because I'm a director now," Barrymore said in a recent interview. "But, you know, they'll make their choice."
"Eclipse" is slated for a summer 2010 release.
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Chris Weitz ("The Golden Compass") is directing "The Twilight Saga: New Moon," the second film based on Stephenie Meyer's best-selling series. He took over the franchise from "Twilight" director Catherine Hardwicke.
"New Moon" will be in theaters in November.
Barrymore directed "Whip It!" starring Ellen Page ("Juno"), due in theaters this year.
She stars in the upcoming HBO movie "Grey Gardens," co-starring Jessica Lange and Jeanne Tripplehorn.