While they have fared well in the past in replacing key players, it is clear Peyton Manning is not any other player.
The Colts avoided a shutout when Collins hit Reggie Wayne for a 6-yard touchdown pass in the fourth quarter, the only scoring of the second half for either team.
Of concern is starting middle linebacker Gary Brackett who sprained a shoulder following a second-half interception.
The 27-point loss is the worst in a season opener since the 1985 season when the Colts lost 45-3 at Pittsburgh.
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