Duke's run at No. 1 ended with a court-storming loss at Boston College and No. 2 Kansas wilted in a rare home loss.
Undaunted and undefeated, Villanova is charging toward the top spot.
"We played the next No. 1 team in the country," La Salle coach John Giannini said Sunday.
The Explorers got a taste of how tough it can be to knock off the Wildcats. La Salle scored more baskets, sank more 3-pointers, had more steals and still was just another victim in Villanova's unbeaten season.
Phil Booth scored 18 points and Donte DiVincenzo had 18 points and 10 rebounds to help the fourth-ranked Wildcats avoid an upset in a 77-68 win over La Salle.