They first met on Jan. 18, 1996. UConn beat Notre Dame 87-64 in South Bend, the first of 11 consecutive wins by the Huskies.
Two decades later, the teams will meet for the 46th time Wednesday night. The former Big East foes have played for national titles and have become heated rivals.
UConn holds a 34-11 lead in the series and has won the past five meetings. Really, the Huskies have dominated the rivalry aside from a stretch from 2011 to 2013 when Notre Dame won seven of eight.
There have been six meetings in the Final Four. Each team has won three times.
Let's take trips through Storrs, South Bend and beyond as we revisit some memorable games: