Notre Dame and Wisconsin will play at Lambeau Field in Green Bay, Wisconsin, in 2020 and Soldier Field in Chicago in 2021.
The schools made a joint announcement on Monday in Chicago. The two-game series marks the first meeting between the Fighting Irish and Badgers since 1964.
Notre Dame athletic director Jack Swarbrick says the games will be part of school's Shamrock Series in which the Irish regularly play at a neutral site and break out alternative uniforms.
"These things are always a Rubik's Cube when you're trying to figure out how to put them together," Swarbrick said. "One piece of it moves, then you've got to go back and try and refigure it....