The one-hour drama is inspired by Michael Crichton's 1973 Western thriller about the dawn of artificial consciousness and the future of sin.
Eddie Rouse has also been cast for the role of Kissy, a laconic American-Indian who deals cards and contraband from the town saloon.
Anthony Hopkins, Evan Rachel Wood, Jeffrey Wright, Rodrigo Santoro, Shannon Woodward, Ingrid BolsÃ¸ Berdal, Angela Sarafyan and Simon Quarterman will also star.
Jonathon Nolan is set to write and direct. Executive producers include J.J. Abrams, Jerry Weintraub and Bryan Burk.
Marsden can be seen in the upcoming Nicholas Sparks film "Best of Me" and "Business Trip" with Vince Vaughn.
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