Shailene Woodley and Ansel Elgort attended Sunday night's MTV Movie Awards to introduce a new clip from their film, "The Fault in Our Stars."
"That's the thing about the story -- it's a cancer book, a cancer movie, that's not about cancer," Woodley told Variety. "It's about love and it's about universal messages. It's a celebration of life."
John Green's novel, is a story about two teens that fall in love after meeting at a cancer support group.
Green said he was truly inspired from the actors' dedication.
"With characters like that you have to be really authentic and real, and I wanted to bring a sense of authenticity and truth to them," said Woodley.
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Nat Wolff was so dedicated to playing his blind character Isaac that he filmed his parts with either contacts or black tape over his glasses that prevented him from seeing.
"I almost brushed my teeth with Tiger Balm," said Wolff. "Goes to show you don't leave Tiger Balm out if you're blind."
On a serious note, Wolff added, "It's probably the hardest part I've ever played because it was balancing the comedy of my character and also the reality of it -- which is going blind and getting dumped."
Meanwhile, host Conan O'Brien kicked off the show at Nokia Theater with fire, explosions and rap music. "All things you associate with Conan O'Brien. Am I right?" he said.
Recent Academy Award winners Lupita Nyong'o and Jared Leto took to the stage as she presented Leto with the award for onscreen transformation for his role in "Dallas Buyers Club."
Leto's given so many acceptance speeches this season, he's now a master inspirational speaker. "Love who you want to love, live how you wish to live and never let anyone ever stop you from turning your dreams into your reality," he said.
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MTV stuck with its lighthearted antics as O'Brien joked that instead of using music to wrap up acceptance speeches he would personally send a dick pic to the Teleprompter.
And when it came to MTV's famous category for kiss, "Neighbors" stars Seth Rogen, Zac Efron and Dave Franco kissed three lucky fans before handing out the award to "We're the Millers'" Will Poulter.
"Wait a minute â¦ that's my mom," said Rogen of his kissing partner. "Mom? No, mom, no. This is a total nightmare."
Efron showed off his abs after singer Rita Ora ripped off his shirt for winning shirtless performance. The "That Awkward Moment" actor beat out "Catching Fire's" Sam Claflin, "Thor's" Chris Hemsworth, Leonardo DiCaprio and even Jennifer Aniston and her stripper scene from "We're the Millers."
Jonah Hill presented Channing Tatum with the trailblazer award, while Mark Wahlberg f-bombed his way through his generation award speech.
"This is you're-too-fucking-old to come back award," he quipped.
Johnny Depp presented the last award of the night for movie of the year to "The Hunger Game: Catching Fire," when Josh Hutcherson thanked the late Philip Seymour Hoffman. "We think about him every day on set, so wherever he is, this goes out to him, too."
Performers included Rihanna and Eminem with their first televised performance of "The Monster," Ellie Goulding and Zedd.
Cameron Diaz, Leslie Mann, Nicki Minaj, Kate Upton, Bella Thorne, Miles Teller, Chris Pratt, Ellen Page, Orlando Bloom, Mila Kunis, Seth MacFarlane and Ice Cube also made appearances.
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