Knox, who was sentenced to 28 1/2 years in prison, is scheduled to speak with ABC's Robin Roberts on Friday morning on "Good Morning America."
This isn't the first time Knox has agreed to an exclusive sit-down with ABC. Last year Diane Sawyer interviewed the controversial student following her 2012 acquittal in Florence, Italy.
In a statement from Seattle, where she had awaited the verdict, Knox said she was "frightened and saddened" by the decision, which she said was unjust and the result of an overzealous prosecution and narrow-minded investigation.
"This has gotten out of hand," she said. "Having been found innocent before, I expected better from the Italian justice system."
After nearly 12 hours of deliberations, the court reinstated the guilty verdicts first handed down against Knox and Sollecito in 2009 for the death of Meredith Kercher. Those verdicts had been overturned in 2011 and the pair freed from prison, but Italy's supreme court vacated that decision and sent the case back for a third trial in Florence.
Knox's attorney, Carlo Dalla Vedova, said he had called Knox by telephone and informed her that the Florence court had not only confirmed the guilty verdict, but had increased the sentence from the original 26 years.
"She was petrified. Silent," he said.
Knox had returned to Seattle after spending four years in jail before being acquitted in 2011. In an email to this court, Knox wrote that she feared a wrongful conviction.
The first trial court found Knox and Sollecito guilty of murder and sexual assault based on DNA evidence, confused alibis and Knox's false accusation against Patrick Lumumba, a Congolese bar owner, which resulted in a slander verdict that has been upheld on final appeal. A Perugia appeals court dismantled the guilty verdict two years later, criticizing the "building blocks" of the conviction, including DNA evidence now deemed unreliable by new experts, and the lack of motive.
Knox scored a $4 million book deal with HarperCollins following her 2012 acquittal and appeared on numerous talkshows since leaving Italy behind.
She was also the subject of a Lifetime TV movie called "Amanda Knox: Murder on Trial in Ital," starring Hayden Panettiere.
Associated Press contributed to this report.
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