The actress is in talks to topline the Fox project, the studio confirmed.
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Feig will direct and produce through his Feigco Entertainment shingle, which signed a first-look deal with Fox earlier this year.
McCarthy has been shooting road-trip comedy "Tammy," which Warner Bros. has dated for July 2, 2014. The New Line project stars McCarthy, Allison Janney, Susan Sarandon and Mark Duplass; McCarthy is co-directing with spouse Ben Falcone. McCarthy and Falcone are also producing from a script they co-wrote.
The web site The Wrap first reported McCarthy's attachment to "Susan Cooper."
McCarthy is repped by CAA.
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