The Gators (6-0, 5-0 SEC) will look keep their unbeaten season alive against the man who built Florida into one of the nation's premiere programs in the 1990s.
South Carolina (6-1, 4-1 SEC) fell from the unbeaten ranks on Saturday night with a 23-21 loss at LSU and will be a desperate team against Florida, which sits along atop the SEC East.
On the heels of Saturday night's 31-17 win at Vanderbilt, the Gators moved to No. 3 in the AP poll and No. 4 in the USA Today Coaches Poll. Florida is expected to check in as high as No. 3 when the first BCS Standings are released at 8:30 tonight on ESPN.
Spurrier, who coached Florida to six SEC titles and a national championship, will look to get in the way of the Gators' dreams of a third national title since 2006.
South Carolina eked by Florida and first-year coach Will Muschamp 17-12 last season in Columbia, but whipped the Gators 36-14 in 2010.
And who can forget the epic 2006, when Florida defensive end Jarvis Moss blocked three kicks, including the winning field goal, in a 17-16 win that ignited the Gators' run to their first of two national championships under Urban Meyer.