The Heisman Trophy winner tweeted: "Bulls--- like tonight is a reason why I can't wait to leave college station...whenever it may be."
The post was quickly deleted and replaced with a follow-up post: "Don't ever forget that I love A&M with all of my heart, but please please walk a day in my shoes"
Manziel took a break from Twitter this past spring after citing social media as being a distraction.
The Aggies signal caller created a small stir when pictures of Manziel on Spring Break showed him in a Texas Longhorns tattoo - a big rival of A&M.
It is not expected that Manziel will ever address the deleted tweet.