The Gators (4-5, 3-4 SEC) are mired in a four-game losing streak following a historic 34-17 loss to Vanderbilt. Meanwhile, the No. 12 Gamecocks (7-2, 5-2) are a game behind Missouri in the SEC East race.
South Carolina also is coming off a bye week with the memory of last season's 44-14 beatdown in Gainesville to serve as extra motivation.
Spurrier is 3-5 against his alma mater and former employer, including 1-1 against coach Will Muschamp. In 2011, the Gators lost 17-12 in Columbia on their way to a 6-6 regular season.
After Saturday's collapse to Vandy, losers of 22 straight to Florida entering the day, the Gators are well on their way to their first losing season since 1979.