Busch Stadium, home of the St. Louis Cardinals, will play host to its first-ever college football game.

Southeast Missouri State and Southern Illinois will continue their longtime rivalry when the two schools meet on Saturday, Sept. 21.

“We are thrilled to host our first football game in Busch Stadium with two great schools that have such a large following in St. Louis,” said Bill DeWitt III, President of the Cardinals said on the team’s website. “We are excited to showcase the versatility of Busch Stadium as a multi-use sports venue.”

The stadium holds more than 46,000 fans, but based on configuration for a game, it’s hard to estimate how many seats will be available.

It’s not the first time a Major League Baseball Stadium has hosted a college football game.

Yankees Stadium has hosted several neutral-site games with Army and Notre Dame as well as the Pinstripe Bowl while Wrigley Field played host to Northwestern and Illinois in 2011. AT&T Park host the Kraft Fight Hunger Bowl as well.

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