Defensively, Indiana is a bear, holding teams to just 89.7 points a game. The Lakers score 102.4 points nightly, but can they get close to that with Kobe Bryant on the shelf with a severely sprained ankle?
Now's the chance for Dwight Howard to truly carry the team as Bryant misses his first game of the season.
Howard scored 17 points with eight rebounds against the Pacers, blocking four shots as the Lakers held Indiana to just 36.7% shooting. The Lakers were even worse at 31.6% -- generating offense Friday may be a struggle.
The Pacers start 7-foot-2 center Roy Hibbert, who is significantly taller than the (barely) 6-foot-11 Howard.
Hibbert has struggled offensively this year, scoring 10.7 points on 43.5% shooting, but he's a presence inside defensively. The Pacers center is averaging 2.7 blocks a game along with eight boards.
Reserve Ian Mahinmi also had a strong game against the Lakers in November, scoring 11 points while getting to the line 10 times.
The Lakers always seem to have trouble guarding David West. In their last meeting, the Pacers forward was two assists away from a triple-double.
Jodie Meeks and Steve Blake are the likely pair to get the bulk of Bryant's minutes. Meeks is more of a scorer, although he's primarily a spot-up shooter.
Blake can help the Lakers into their offense, paired next to Steve Nash. Indiana's Lance Stephenson isn't a major scoring threat to punish Blake's lack of height.
The Lakers also will have to deal with Hill and All-Star Paul George. The Pacers are a tough, physical team that is used to grinding out difficult wins.
It's still not clear how long Bryant will be out, but even at full strength the Lakers would have a difficult time getting a win in Indiana.ALSO: