The mission is celebrating its 76th year of providing more than 3,500 meals for the city's homeless.
This year's event features food preparation by "Top Chef" winner Michael Voltaggio, who owns the L.A. restaurant "Ink."
He's helping dish up some 3,000 pounds of smoked turkey, 700 pounds of corn and maple stuffing, 80 gallons of gravy and 800 pounds of vegetables.
The mission is also serving twice baked potatoes, spaghetti squash casserole and pumpkin pie.
In addition to the meal, each person will receive a tarp, tent and a blanket.
The Los Angeles Christian Health Centers will also be providing foot care and exams.
Multiple celebrities are expected to be on hand to help out with the event, including Hillary Duff, Neil Patrick Harris, Kirk Douglas and Blair Underwood.