Clooney's "The Descendants" won for best drama film, while Clooney received the best actor in a drama film award.
The Globes set the stage for a Meryl Streep versus Michelle Williams best actress showdown at the Academy Awards in six weeks by handing both women best actress honors.
Streep won the drama film best actress Globe for her portrayal of former British Prime Minister Margaret Thatcher in "Iron Lady," while Williams carried home the comedy or musical film Globe for playing movie legend Marilyn Monroe in "My Week With Marilyn."
Since the Globes separates dramas from comedies -- unlike the Academy Awards -- Williams, Streep, Clooney and Dujardin were not competing against each other in the 69th annual Golden Globes award show.
"Thank you to the Hollywood Foreign Press Association for putting in my hand the same award that Marilyn Monroe herself won over 50 years ago," Williams said in her acceptance speech.
Oscar nominations will be revealed later this month and the Academy Awards follows at the end of February.
Other films expected to be Oscar contenders also got a share of the Globes spotlight.
Woody Allen's "Midnight In Paris" lost out to "The Artist," but Allen did win for best film screenplay.
The 3-D family movie "Hugo" was also passed up, but Martin Scosese got the best director award for making the film.
The civil rights-era movie "The Help" claimed the best supporting actress award for Octavia Spencer.
Spencer, who played a maid in the movie, quoted Dr. Martin Luther King Jr. in her acceptance: "All labor that uplifts humanity has dignity and importance."
Although the "Help" characters are fictional "they represent scores of real people," she said.
"The narrative itself is part of our fabric," Spencer said backstage. "It's important to keep the younger generation abreast of how far we've come, because this is really foreign to them."
Christopher Plummer won the Golden Globe for best supporting actor in a film for his role in "Beginners."
Steven Spielberg's "The Adventures Of Tintin" won the Golden Globe for best animated feature film.
The best foreign-language film honor was awarded to the Iranian film "A Separation."
Pop icon Madonna took home a Golden Globe for writing the best original song in a movie. Her "Masterpiece" was written for "W.E."