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Story | Sep 30, 2013 | 6:30 AMDiuretics are usually prescribed as a first-line treatment for high blood pressure, though many people require additional drugs for blood pressure management, such as beta blockers, ACE inhibitors, or angiotensin-receptor blockers (ARBs). Diuretics help lower blood pressure by reducing the amount of sodium and water in the bodyâthe lower the volume of fluid in the bloodstream, the less pressure there is on the walls of the arteries. They're also prescribed for kidney disorders, liver disease, and fluid retention caused by heart failure.