The Titans (13-8, 5-3 Horizon) shot 76 percent from the field in the second half as they broke down the usually fundamentally sound Ramblers 75-63.
Loyola continued its travails against Horizon League opponents at Gentile Arena. The Ramblers (12-8, 2-5) are just 10-30 at home against conference foes since the 2008-09 season.
"I don't know what the issue is," Moser said. "I look at some of the games on the road and the toughness we've had … you can't have 17 turnovers (against Detroit)."
The Titans had five players in double figures, including Ray McCallum with 17.
McCallum, a 6-3 junior point guard whose father Ray is the Titans' coach, is regarded as the top player in the Horizon League and several NBA scouts were in attendance Saturday, including former DePaul coach Joey Meyer, who scouts for the Clippers, and the Bulls' John Bach.
"At the beginning of the game I tried to get everyone shots and get everyone going," McCallum said. "(Later) I had to look to make plays, whether for myself or something to help the team. I stayed patient and I had a little run in the second half (11 points)."
Sophomore swingman Christian Thomas achieved his fourth double-double (18 points, 11 rebounds) in the last nine games as he "played the hardest possession-by-possession than anyone in the gym," Moser said.
"I looked at Christian Thomas and walked away and said: 'Man, that kid is a warrior.' For us to be good I have to be able say that same thing about seven guys."
Loyola led 27-24 at the half while limiting Detroit to 29 percent shooting.