Obama will "talk about the gun violence that has tragically affected too many families in communities across Chicago and across the country," a White House official said in a statement.
The mother of Hadiya Pendleton, 15, whose shooting death at a South Side park drew national attention to Chicago's gun violence, plans to attend the president's address in Washington, family spokeswoman Shatira Wilks said late Sunday.
The president's visit answers calls from Chicago anti-violence activists that Obama talk about the recent spate of gun violence in the city, several of the activists said.
"This is an important issue," said Cathy Cohen, founder of the Black Youth Project, which attracted about 45,000 signatures by Sunday night in an online petition that urges Obama to speak up. "We think of this as a victory for all of us."
The group posted the petition on change.org shortly after Hadiya, a King College Prep student, was slain about a week after performing with her school band at Obama's inaugural festivities.
Because the teen was shot about a mile from the president's Kenwood neighborhood home Jan. 29, during the deadliest January for Chicago since 2002, pastors, parents and activists have demanded that more be done about the city's violence.
First lady Michelle Obama attended Hadiya's funeral Saturday, but Hadiya's godmother, LaKeisha Stewart, said she hasn't heard whether the president will spend time with the Pendletons during his trip.
Stewart said she's happy about Obama's plans. "Any awareness that can be brought to this issue that can prevent any family from ever feeling the pain that we as a family have felt … is awesome," she said. "This city is in pain right now."
Nathaniel Pendleton, Hadiya's father, said, "If (Obama) decided to speak with us, we'll be more than happy."
The Rev. Jesse Jackson said the president's remarks will play a different role than Michelle Obama's attendance at Hadiya's funeral. The first lady didn't speak publicly about the teenager's death.
"Her being there is very important since it was her neighborhood," Jackson said. "I think the president's coming is important because she did not deal with the politics. … She dealt with the calming concern for a broken-hearted family," he said.
Jackson made an appeal this month for the president to speak to the bloodshed in Chicago.
Because of the upcoming visit, parents of children who have been shot to death in the city will finally feel heard by Obama, said Annette Nance-Holt, who lost her son Blair Holt in 2007 after he was shot on a crowded CTA bus.
"This sends a message to the parents here that their kids are important too," Holt said. "It may not have been a big shooting with an assault rifle. But to see (Obama) come and hopefully rally some support here means a lot."
The White House said the president's visits to Asheville, N.C., Atlanta and Chicago this week will also press issues that he will raise in his speech Tuesday.
"The president will travel to Chicago for an event amplifying some of the policy proposals included in the State of the Union that focus on strengthening the economy for the middle class and the Americans striving to get there," a White House official said in a statement.
Clergy on Sunday praised Obama's decision to speak in Chicago, arguing his speech could bring greater attention to the killings.
"Hopefully and prayerfully, his coming will make a real impact," said the Rev. Kenneth Giles of Second Mount Olive Missionary Baptist Church in the South Austin neighborhood.
The Rev. Michael Pfleger, senior pastor of the South Side's St. Sabina Catholic Church, said he's grateful the president is "zooming in" on the issue.