Josh Beckett, Marlins, 22: His first full big-league season will be memorable, provided he doesn't have a recurrence of his problem with blisters.
Johan Santana, Twins, 23: Starts the season back in Minnesota's bullpen but almost certainly will end it as one of the Twins' best starters.
Aaron Cook, Rockies, 24: Brings serious heat and could follow Jason Jennings to give Colorado back-to-back rookies of the year in its rotation.
Francisco Rodriguez, Angels, 21: So far it doesn't look like K-Rod is feeling the effect of being ridden so hard in last year's playoffs, but Mike Scioscia should handle him carefully.
John Lackey, Angels, 24: Victory in Game 7 of the World Series was his 19th victory of last season, when he worked 232 innings between the minors and majors.
These players couldn't quite crack the list of the best pitchers who open this season at 25 or younger, but they are worth noting:
PITCHER TEAM AGE Ben Sheets Brewers 24 Joe Kennedy Devil Rays 23 Odalis Perez Dodgers 25 Jason Jennings Rockies 24 Jorge Julio Orioles 23 Kip Wells Pirates 25 Brad Penny Marlins 24 Tony Armas Jr. Expos 24 Kyle Lohse Twins 24