SAN DIEGO—White Sox manager Ozzie Guillen took an immediate liking to Petco Park in his first visit Friday night.
The deep dimensions worked in favor of Jon Garland, who didn't yield a hit until the fifth inning and pitched six shutout innings before tiring.
And the Sox's emphasis on manufacturing runs came through when they scored twice on two-out hits in the second.
That added up to a 4-2 victory that helped Garland become the American League's first 10-game winner.
The Sox (41-19) have won four straight, and this equals their best 60-game start in franchise history.
"Things have been going my way this year, and hopefully it continues," said Garland, who said he hasn't looked ahead to a potential All-Star invitation or a 20-win season.
Garland (10-2) had suffered his only two losses in his past two road starts. He had a 6.92 ERA in those games against Anaheim and Texas.
However, "this park plays well for him," Guillen said.
Garland pitched efficiently through the first six innings. He pitched to the minimum 13 batters until Phil Nevin lined an opposite-field double down the right-field line in the fifth.
"Jon goes back to being big Jon this outing," Guillen said. " It's fantastic."
There were no signs of trouble until the seventh, and Garland received some timely help after surrendering four consecutive hits, the first a home run by Brian Giles.
Rowand bobbled Carlos Hernandez's single that enticed Phil Nevin to try to advance from second to third.
But Rowand recovered to make an accurate, one-hop throw to third baseman Joe Crede. Umpire Marty Foster called Nevin out, prompting a heated argument from Nevin that eventually resulted in the ejection of San Diego manager Bruce Bochy.
Rowand made an even bigger play after the Padres moved the tying run to second base with two outs.
Khalil Greene hit a line drive to shallow center. But Rowand, sprinting all the way, made a diving catch while landing hard on his left wrist.
"I tell you guys after each start I live and die by defense, and you saw it tonight," Garland said. "Rowand picked me up huge."
Said Rowand: "It's something we made an effort to get better on, and we have. I'm just trying to do my part out there.
"I knew I had a chance to catch that ball."
In the ninth, shortstop Juan Uribe made a long, accurate throw to retire Giles, and Crede made a diving stop to rob Nevin of a hit and help closer Dustin Hermanson notch his 15th save in as many opportunities.
"Defense wins games," Guillen said. "Defense helps pitching staffs. We executed very well."
Garland helped his cause in the second by delivering a two-out RBI single for a 2-0 lead.
"I'm going to say I got lucky," said Garland, who became the third Sox pitcher to collect a hit in interleague play. "We take batting practice a week before [interleague play] comes up. We get a few swings and get out of there."
The Sox also picked up their fifth pinch-hit of the season and second in as many games when Timo Perez perfectly executed a hit-and-run play in the eighth that moved Crede to third.
Crede, who went 3-for-4 after a 4-for-31 slump, scored on a wild pitch by reliever Rudy Seanez.