The Wildcats (13-2, 4-1 American Lacrosse Conference), who have won seven NCAA championships in the past eight years, suffered their worst loss since the program returned to Division I 12 years ago.
Florida also clinched a share of the American Lacrosse Conference regular-season crown for the third straight year.
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"We're a pretty confident team, but this definitely will give us more confidence going against some of the big teams," said Brittany Dashiell (John Carroll), who had a hat trick. "We'll watch this game over and over to see what we were doing right, but every game is different. We may have won this one by 18, but it's not going to happen that way again. Every game is different, so we just have to stay focused and keep moving on."
The Gators (16-1, 5-1) won the opening draw and scored 30 seconds into the game. They won the second draw and scored 31 seconds later, and then again 26seconds after that. Barely 10 minutes into the game, Florida led 5-0 on the way to a 13-2 edge at halftime, an output that matched the most goals Northwestern had given up to any opponent this season — or in the past three seasons.
The Gators' Shannon Gilroy scored a game-high five goals.
No. 3 North Carolina 20, Vanderbilt 5: The visiting Tar Heels (13-2) jumped to a 12-0 first-half lead powered by a trio of three-goal scorers (Kara Cannizzaro, Brittney Coppa of North Carroll and Abbey Friend).
Carolina improved to 17-1 all time against the Commodores (2-13).
Duke led 7-3 at halftime and outshot Ohio State 24-22 and won more ground balls, 15-14.
The game was originally scheduled for Saturday at 1 p.m. Both universities, in conjunction with the America East Conference, made the decision to reschedule the game to protect the safety of the BU students and staff.
No. 13 Princeton 15, No. 16 Dartmouth 13: The visiting Tigers (9-5, 6-1 Ivy League) scored the last three goals over the final 4:59 to secure the win over the Big Green (8-6, 4-2) and a share of the conference title.
Mary-Kate Sivilli and Sarah Lloyd (Severna Park) each had a hat trick for Princeton in a game that featured seven ties. Hana Bowers and Sarah Byrne each had three goals for Dartmouth.
Canisius at No. 15 Boston College, ppd.: The host Eagles (10-6) and Golden Griffins (11-3) will play today at 1 p.m.