After leading 3-1 at halftime, the Fighting Irish (10-3, 4-2 Big East Conference) were held to three shots on goal in the second half as the Orange (11-3, 5-1) put the game out of reach.
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Rob Pannell scored five goals and added four assists to lead Cornell.
No. 14 Yale 11, Harvard 10: The host Crimson (6-8, 2-4 Ivy League) fell short in its comeback effort against the Bulldogs (9-4, 4-2).
Yale came out of halftime with four unanswered goals to lead 9-5. But Harvard came back to cut the lead to two in the fourth quarter.
After the Bulldogs scored to lead by three, the Crimson scored twice in the final two minutes and trailed 11-10 with 30 seconds left, but couldn't get the tying goal.
After taking a 2-1 lead in the first quarter, Michigan allowed five unanswered goals as Denver took control.
With the score tied heading into the fourth quarter, Fairfield allowed a 7-1 run to end the game.
Penn State scored the most goals against Hofstra since 2010.
Miles Thompson had 14 points (five goals, nine assists) to lead Albany.
No. 15 Drexel 14, High Point 8: The visiting Panthers (3-12) cut the lead to 7-5 before the Dragons (11-3) took control with a 6-0 run in the third quarter.
Ben McIntosh had four goals and two assists for Drexel.
St. John's scored six unanswered goals to take a five-goal lead with 5:45 remaining in the first half.
No. 19 Penn 10, Bellarmine 5: Led by Zack Loso's three goals, the Quakers (8-4) led 6-2 at halftime en route to a victory over the visiting Knights (7-7).