Even after fighting back to tie the game in the fourth quarter, host No. 2 seed Syracuse could not break through against Bryant, which never trailed en route to a 10-9 upset on Sunday night.
Led by attacker Tucker James' four goals and two assists, the Bulldogs (16-4) surprised the Orange (11-5) in the first round of the NCAA Division I tournament. Bryant will face Maryland in a quarterfinal Saturday at Hofstra.
The Orange outshot the Bulldogs 38-27, but Bryant goalkeeper Gunnar Waldt made 13 saves and his team won 14 of 23 faceoffs.
Midfielder Myles Jones, who scored twice in the first 10 minutes to help Duke (14-3) to a 5-2 first-period lead, finished with a game-high eight points on three goals and five assists. The Blue Devils outshot Air Force (11-6) 52-35 and outscored the Falcons in each quarter. Duke advances to play Johns Hopkins on Sunday at Delaware.
Drexel 16, No. 4 Penn 11: The Dragons, playing in their first NCAA tournament, surged in the second quarter to upset the host Quakers.
Penn (11-4) scored the first two goals and led 4-3 after the first quarter. But the Dragons (13-4) took a 7-6 edge just before halftime, then scored the next four goals. Drexel will play No. 5 seed Denver on Sunday at Delaware.
No. 2 Syracuse 13, Stony Brook 6: The Orange (19-2) tied its record for most wins in a season as attacker Alyssa Murray's four goals paced Syracuse in a rout of the visiting Seawolves (17-4) in the second round.
Murray scored the Orange's first four goals in the opening 10 minutes, and Syracuse jumped out to a 10-2 halftime lead. The Orange will play No. 7 seed Boston College in a quarterfinal Saturday.
No. 3 seed North Carolina 10, Georgetown 8: The Tar Heels distanced themselves from the visiting Hoyas with a late four-goal rally, and North Carolina attacker Abbey Friend scored four times for a program-high 195 career goals.
North Carolina (15-4) outshot the Hoyas (11-9) 14-9 after the break, and goalkeeper Megan Ward (St. Mary's) made eight saves. The Tar Heels will play Virginia on Saturday.
Attacker Devon Schneider and midfielders Mollie Stevens and Shannon Gilroy combined for 12 goals for Florida (18-2), which will play Northwestern on Saturday.
No. 5 Northwestern 11, Louisville 8: Attacker Kara Mupo scored four goals to lead the host Wildcats past midfielder Cortnee Daley (four goals) and the Cardinals.
Northwestern (13-6) led 4-3 at halftime. Louisville (16-4) went ahead, 5-4, with 26:23 left, but the Wildcats responded with four straight goals. Northwestern will play Florida on Saturday.
No. 6 Virginia 13, Princeton 11: The host Cavaliers (11-8) scored the first four goals, but the Tigers (12-7) came back to within 5-4 and matched Virginia's four-goal second-half run with one of their own to keep the game close.
The Cavaliers will play North Carolina on Saturday.
Duke 10, No. 8 Notre Dame 8: Midfielder Maddy Morrisey paced the Blue Devils (11-7) with a career-high six points on four goals and two assists in Duke's second-round victory over the host Fighting Irish (10-9).
The Blue Devils jumped ahead with a five-goal run that spanned halftime. The Blue Devils will face No. 1 Maryland on Saturday.