Stay here: Hotel Bethlehem, 437 Main St., 800-607-2384. In the heart of downtown Bethlehem, the Hotel Bethlehem is in an ideal location for those looking to explore the town. The hotel takes pride in its history, even claiming the residence of 18th-century friendly ghosts around the premises. Rooms start at about $129.
Don't miss this: Moravian Museum of Bethlehem, 66 West Church St., 610-691-6055. Learn the history of Bethlehem's founders with a visit to the "largest 18th-century log building in the United States." The museum includes a church, apothecary and school.
The annual Christkindlmarkt was voted among the top holiday markets in the world by Travel+Leisure magazine. The German-style tented outdoor market features aisles of handmade arts and crafts, holiday music and German and Austrian food.
Get here: Take Interstate 95 North to Interstate 495 around Wilmington. Return to I-95 North, heading toward Chester, Pa., and exit to Route 476. Follow 476 until it meets the Pennsylvania Turnpike. Continue north on the turnpike (Northeast Extension-Route 476) to exit 33, which leads to the Lehigh Valley. Follow Route 22 east to the Bethlehem exit.