The school, Maryland's oldest historically black college and one of the oldest in the nation, is celebrating its 148th anniversary. The school is "part of the rich legacy of historically black colleges and universities that have been instrumental in educating generations of African Americans," the White House said in its announcement.
Obama will also speak at Eastern Kentucky University and a Tennessee high school, the White House said.
The announcement comes a day after the first lady entered the policy debate over gun control with a deeply personal address on violence to a conference in Chicago.
The White House announced in March that President Barack Obama will speak at the Naval Academy graduation in May, the first time he has done so since 2009.