Lewis, who did not play in Sunday’s victory over the Cincinnati Bengals because of an injured toe on his right foot, had practiced on a limited basis in each of the past three days. He had been listed as questionable in the team’s final injury report on Wednesday, but has been deactivated by the Ravens.
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Brendon Ayanbadejo will join Jameel McClain as the defense’s starting inside linebackers. Ayanbadejo’s last start took place on Oct. 4, 2009 against the New England Patriots.
In addition to Lewis and Ellerbe, the team deactivated cornerback Chris Carr (back), defensive tackle Arthur Jones (post-concussion symptoms), outside linebacker Sergio Kindle, rookie running back Anthony Allen (thigh) and wide receiver Tandon Doss.
Safety Haruki Nakamura (thigh), who had been upgraded from limited to full participation Wednesday and was listed as probable, is active.
Wide receiver/kick returner David Reed is also active. He was scratched against the Bengals after fumbling three kick returns in his previous two contests.
For San Francisco, four starters – wide receivers Michael Crabtree (foot) and Braylon Edwards (knee), running back Frank Gore (knee) and right tackle Anthony Davis (ankle) – will play Thursday night.
The 49ers deactivated guards Daniel Kilgore and Mike Person, cornerback Shawntae Spencer, quarterback Scott Tolzien, wide receiver Brett Swain, fullback Bruce Miller and nose tackle Ian Williams.