Here's a look at the highlights and lowlights around the NFL during the opening weekend:
1. Peyton Manning is back.
The Denver Broncos' quarterback made an early statement in his bid for NFL Comeback Player of the Year honors.
The four-time Most Valuable Player completed 19 of 26 passes for 253 yards and two touchdowns, displaying zip on his throws and a command of the Broncos' offense. He fired a 71-yard touchdown pass to wide receiver Demaryius Thomas.
Manning also threw his 400th career touchdown pass, reaching the milestone faster than Dan Marino or Brett Favre did. Manning now has 401 for his career, only ranking behind Favre (508) and Marino (420) in NFL history.
Most importantly, Manning also displayed that his neck is sturdy as he was sacked twice and got up without any injury setbacks.
2. Robert Griffin III dazzles.
The Heisman Trophy winner from Baylor has energized the Redskins, passing for 320 yards, two touchdowns and no interceptions on 19 of 26 accuracy for a 139.9 quarterback rating.
Griffin was extremely poised and selective about when he chose to leave the protective confines of the pocket. Only once did he get hit hard.
Griffin's decision-making was sharp and he completed his first eight passes, including an 88-yard touchdown pass to Pierre Garcon over the middle. His timing with Garcon was superb.
Reprising their old connection from their days with the Broncos, Cutler and Marshall collaborated for nine completions, 119 yards and a touchdown in the Bears' win over the Indianapolis Colts.
4. Matt Ryan is sharp
Ryan and wide receiver Julio Jones are one of the most potent tandems in the league. Jones caught six passes for 108 yards and two touchdowns.