Late Tuesday afternoon the Colts placed Collins on injured reserve, ending his season after playing in just two-and-a-half games.
Collins hasn't seen the field since suffering a concussion in the second half of the Colts loss to Pittsburgh in the third game of the season.
When it became clear that Manning wouldn't be ready for the first game of the season, the Colts added Collins to the roster before their final preseason game of the season. He was given a two-year contract worth 14 million dollars to come out of retirement to play in Indianapolis.
Collins appared in that game against Cincinnati for a half and was declared the starter for the opening game against the Texans.
Things didn't go well in the opening start, with Collins fumbling the ball twice as the Colts were blown out by the Texans 34-7. A second start against the Browns saw Collins complete 19-of-38 passes for 191 yards with a touchdown and an interception. Long drives, however, weren't converted into touchdowns as the Cotls were upended by Cleveland at home 26-19.
Collins was 13-of-29 passing against the Steelers with 97 yards but was knocked out of the game with concussion-like symptoms. Since then, Collins was unable to return to full time practicing and wasn't on the active roster again.
The status of the quarterback was one of many moves by the team on the off day, during which fullback Chris Gronkowski was also place on injured reserve. It was also announced that starting guard Joe Reitz had arthroscopic knee surgery and will be out for an "unspecified time."
To make up for the losses, the Colts signed offensive guard Jamey Richard and offensive tackle Michael Toudouze to the active roster while also resigning running back Darren Evans to the practice squad.
Wide receiver David Gilreath was released from the practice squad.