Locklear has been out since he sustained a high right ankle sprain midway through the second game of the season, Sept. 20 at San Francisco.
Walter Jones was supposed to make it back from major knee surgery but didn't and is on injured reserve. Damion McIntosh has started the last two games after signing last month.
Coach Jim Mora also said Friday that Josh Wilson will start at cornerback opposite Marcus Trufant. Wilson has unseated veteran Ken Lucas.
Lucas has been recovering from a neck injury sustained on Nov. 1 at Dallas, but Mora says he is healthy now.