Led by a resurgent Brand, the Sixers have rebounded from a 3-13 start to get to 29-29. Coach Doug Collins had already in his first season led the Sixers to more wins than they had a year ago. The Sixers have won 12 of 16 and are in seventh place in the Eastern Conference.
Andre Iguodala had 21 points, 11 assists and seven rebounds for the Sixers. Thaddeus Young scored 24.
The Pistons used six players. Several Detroit Pistons missed at least part of Friday's shootaround and missed the loss.
Tayshaun Prince, Tracy McGrady, Ben Wallace and Rodney Stuckey did not start. Coach John Kuester wasn't around for the finish -- he was ejected in the second quarter after he was whistled for two quick technical fouls arguing a non-call.
The short-handed Pistons trailed by nine late in the third until Lou Williams and Jrue Holiday hit consecutive 3s that carried the Sixers into a dominant finish.
Iguodala put the exclamation point on. 500 with back-to-back, fast-break dunks that wowed the crowd and sealed the win. Iguodala has tempered his desire to play as Philadelphia's No. 1 scoring option and has put up some of the best all-around numbers of his career since November.
He has the Sixers in prime position to grab a winning record Sunday at Cleveland. The Sixers have not finished above .500 since the 2004-05 season. They went 41-41 two years ago.
The Sixers believed so strongly in their developing nucleus, team president Rod Thorn balked at making a move by Thursday's trade deadline.
Brand scored 10 points in the third quarter to spur the Sixers. When Spencer Hawes missed a dunk off a perfect pass from Iguodala, Brand was there for the put-back.
The Sixers are 26-16 over their last 42 games and have the ninth-best winning percentage in the NBA since Nov. 27.
The Pistons mercifully want this season over.
Team spokesman Cletus Lewis said Richard Hamilton, Chris Wilcox, Stuckey and Austin Daye missed the bus for shootaround, with Stuckey and Daye able to arrive late.
Prince, McGrady and Wallace also missed the shootaround. Lewis said Prince had an upset stomach, McGrady had a headache and Wallace was tending to an unspecified family matter.
Told it was suggested the Pistons had other motives for skipping shootaround, Kuester said, "Sometimes perception is different than reality."
Kuester was tossed in the second quarter -- while McGrady and his teammates laughed as their coach headed toward the locker room.
The Pistons are far removed from the days when Hamilton, Prince and Wallace led the Pistons to the 2004 NBA title.
Will Bynum led the Pistons with 29 points, Charlie Villanueva had 17, and Ben Gordon and Greg Monroe each had 16.
For three quarters, the Pistons kept close on the strength of 52 percent shooting. They didn't have the fresh legs to keep up with a Sixers team that dunked their way toward easy buckets and a 100-87 lead in the fourth quarter.