After a jumper by Saadia Doyle cut the lead to one, Larrisa Carter answered to push the margin back to three with 31 seconds to play. Spotwood and Shawntae Payne each made a pair of free throws to close out the game. Coppin State held Howard scoreless for the final 1:53.
Harris scored 11 and Payne added 10 for the Eagles.
Navy 63, Colgate 48: Jade Geif scored 14 of her 22 points in the first half to power the Mids (17-10, 10-2 Patriot League) past the Raiders (8-19, 2-10).
After trailing by 11 early, Colgate went on an 8-0 run to cut the lead to three but entered the half down nine. Navy opened things up in the second with a 13-4 run and led by as many as 16. Colgate cut the lead to eight with 7:43 left but was outscored 11-4 after that point.
Geif had nine rebounds and Kara Pollinger added 17 points, five rebounds and six assists for the Mids.
Boston University 72, UMBC 51: Raven Harris had six steals to set the single-season school record (95) and scored 15 points, but the visiting Retrievers (10-17, 6-8 America East) were dismantled by the Terriers (23-15, 13-2).
After entering the half down 10, UMBC cut the lead to seven in the second before Boston University went on an 18-4 run to put the game out of reach.
The loss breaks a three-game winning streak for UMBC, which will host Hartford on Wednesday to end itsregular season.
Mount St. Mary's 49, St. Francis (N.Y.) 48: The Mount (12-14, 8-7 Northeast Conference) held on to beat the visiting Terriers (11-15, 8-7) after Jessica Kaufman missed a game-winning layup with 14 seconds left.
After entering the half down one, Mount St. Mary's went ahead 49-44 on a pair of free throws by Tara Lonergan. Kaufman answered with back-to-back layups to cut the lead to one with 1:10 left, but St. Francis could not complete the comeback.
Elizabeth City State 65, Bowie State 51: The Bulldogs (7-16, 4-12 Central Intercollegiate Athletic Association) closed their regular season with a loss to the host Vikings (23-3, 15-1).
After leading 25-21 at halftime, Elizabeth City State started the second half on a 7-0 run led by Stephanie Harper. Bowie State cut the lead to nine twice but could not get any closer.
Channel Mackey scored 15 points and Jasmine McIntosh added 13 points and 11 rebounds for the Bulldogs.