Chris Layne took the ball after a Loyola timeout, dodged down the middle of the field and sent a high-to-low shot into the right side of the net with 4.4 seconds left to propel the top-ranked Greyhounds to a season-opening 9-8 win over host Delaware (1-2) on Saturday.
Loyola was up 7-4 before the Blue Hens scored three goals in the first five minutes of the fourth quarter, tying the game.
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The Greyhounds responded with 8:20 remaining as Sean O'Sullivan scored from 6 yards out.
Delaware drew a flag on Loyola with just over a minute to play and tied the game with 26 seconds left.
The Blue Hens won the ensuing faceoff, but the Greyhounds caused a turnover and gained possession.
Coach Charley Toomey called timeout with 15.4 seconds left to set up Layne's winner.
No. 3 Maryland 16, Hartford 4: Senior Owen Blye scored a career-high five goals as the visiting Terps (2-0) crushed the Hawks (0-1).
Maryland scored its first goal just 1:05 into the game, when Blye came around the right goal line and beat Hartford goalkeeper Frank Piechota.
The Terps then went on a 9-0 scoring run and were up 13-1 midway through the third quarter.
Lynchburg 13, Salisbury 12: The Sea Gulls (0-1) were unable to extend their 31-game winning streak as they fell to the Hornets (1-0).
Lynchburg took advantage of Salisbury's slow start and scored three goals in the first 90 seconds of the game. The Hornets led 7-6 at halftime.
With 15 seconds remaining, Vin Curran put away the game-winning score for Lynchburg.
Robert Morris 12, UMBC 9: Senior attackman Scott Jones scored four goals, but the visiting Retrievers dropped their season opener to the Colonials (1-1).
Freshman midfielder Pat Young added two goals for UMBC, which also lost to Robert Morris in its 2012 season opener.
The Retrievers outshot the Colonials 33-32 and held a 20-16 advantage in shots in the game's final 30 minutes.
Goucher 13, Birmingham-Southern 9: Pierce Ingram scored four goals — including two in the fourth quarter — to help the visiting Gophers (1-0) defeat the Panthers (1-1).
Both teams got off to a slow start in the first half, and Birmingham-Southern carried a 4-2 lead into halftime.
Goucher tied the game after a strong third quarter in which the Gophers scored five goals.
Stevenson 17, Nazareth 11: Mark Pannenton had five goals for the host Mustangs (1-0) as they defeated the Golden Flyers (0-1).
Stevenson scored its first goal 30 seconds into the game and never trailed.
Catholic 9, Hood 1: Doug Brisbane scored the lone goal for the visiting Blazers (0-1) with 14:12 left in the game.
The Cardinals (1-1) led 8-0 after three quarters and outshot Hood 34-25.