The game was the third in a row on the road and the third win for the Tigers, who had not pulled off that feat since 1993. Drexel had won 17 CAA regular-season games in a row, one short of the record set last season by George Mason.
Drexel (5-9, 1-1) was the preseason favorite in the CAA while Towson (7-8, 2-0) won just one game last season and has not had a winning record in league play since joining the CAA in 2001. Mike Burwell and Jerome Hairston added 12 points for Towson.
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Frantz Massenat had 17 points for Drexel and Damion Lee, who played at Calvert Hall, had 14 for the Dragons. Derrick Thomas had 15 points for Drexel.
Massenat missed a pair of 3-point attempts in the closing seconds that would have tied the game.
Langston Galloway added 16 points for the Hawks, who have won three in a row. Halil Kanacevic had a game-high 12 rebounds, five assists and three blocked shots, and junior forward Ronald Roberts Jr. came off the bench to contribute 12 points and 11 rebounds.
Dewayne Jackson had 16 points, eight rebounds and four steals to lead the Bears, who have lost five in a row1.
Mike Phillips led four players in double figures with 15 points for the Bison (4-12, 1-1).
Howard shot 51.2 percent from the field and outrebounded Coppin State 39-29 in ending a four-game losing streak. The Bison were 24-for-31 from the free-throw line, including making their final eight of the game.
Maine 81, UMBC 66: The host Black Bears (7-8, 2-0 America East) won their fourth in a row and their second straight league game.
Justin Edwards and Alasdair Fraser led five Black Bears in double figures with 17 points apiece, while Jon Mesghna had 16. Mike Allison had a double double with 10 points and a team-high 10 rebounds and Xavier Pollard chipped in 10 points and seven assists for the Black Bears.
Mount St. Mary's 71, Monmouth 59: Four players scored in double figures to pace the host Mount (6-7, 1-1 Northeast Conference).
Sam Prescott and Kristijan Krajina each scored 15 while Julian Norfleet and Kelvin Parker added 11 points each in the win.
A 14-5 run midway through the second half sparked the Mountaineers to the victory.
Norfolk State 74, Navy 68: The host Spartans (7-10) built a 26-point lead, then withstood a furious rally by the Mids (6-10) to win.
Navy trailed 54-28 with 13 minutes to play and 56-34 with 10:22 to play when coach Ed DeChellis inserted sophomore guard Kevin Alter into the game. Alter ignited a rally with six 3-pointers in a 10-minute span during which Navy cut Norfolk State's lead from 26 (54-28) to six (71-65) with 13 seconds left.
But Pendarvis Williams made a pair of free throws with 11 seconds left and Navy could get no closer than 73-68.
Bowie State 84, J.C. Smith 80: The host Bulldogs (5-6, 1-1 Central Intercollegiate Athletic Association) took the lead for good on a tip-in by Najee White with 8:13 left in the game.