The Rev. Jesse Jackson Sr. took to his Twitter account to encourage peace.
"If #Zimmerman is not convicted, avoid violence because it only leads to more tragedies. Self-destruction is not the road to reconstruction," Jackson tweeted.
"If #Zimmerman is convicted there should not be inappropriate celebrations because a young man lost his life," Jackson also said.
In the hour after the jury went into deliberations, the hashtag #Zimmerman was used 7,296 times and the hashtag #Trayvon was used 7,270 times on various social media sites.
The jury decided to stop deliberating after 6 on Friday and will resume this morning, which is sure to fuel more social media interest
And in the past 24 hours, "Zimmerman" was hashtaged 197,000 times, and "Trayvon" 133,000 on sites such as Facebook and Twitter.
Another popular social media reaction was the blacking out of profile pictures on Facebook, Twitter and Google+.
Users replaced their normal photos with a black box and used one or all of the following hashtags: #Blackout4Trayvon, #JusticeForTrayvon and #BlackOut.
In the last 24 hours #blackout was used 8,896 times.
Celebrities weighed in on the case, too.
Miley Ray Cyrus tweeted Friday, "may peace be with the Martins as they continue to pray for justice. As will I and anyone else that believes in LOVE #JusticeForTrayvon."
CNN's Piers Morgan tweeted that he thinks the jury will convict Zimmerman of manslaughter in 17-year-old Trayvon's shooting death.
Zimmerman, 29, shot and killed Trayvon, an unarmed black teenager, on Feb. 26, 2012, in Sanford, setting off weeks of civil rights rallies and marches in Central Florida and across the nation and world.
The jury is in deliberations to decide whether Zimmerman is guilty of second-degree murder, guilty of manslaughter, or not guilty.
Click here for full coverage of the George Zimmerman/Trayvon Martin case.
Click here to see evidence photos from the case.
Click here to see pictures from the courthouse while the jury deliberated.
Watch video from the courthouse as the jury considered the case.
Read about the verbal dispute that occurred at the courthouse.