Hitchens died Thursday night at the MD Anderson Cancer Center in Houston, said his literary agent, Steve Wasserman.
His openness about having cancer elicited thousands of letters and e-mails to Vanity Fair, where he was a longtime contributor. Many of the well-wishers offered prayers for the famously atheistic author, who had made his case against religion in the 2007 book "God Is Not Great: How Religion Poisons Everything." He maintained that his illness had not changed his mind about religion and, borrowing from Shakespeare, asked believers not to bother "deaf heaven" with their "bootless cries."
Erudition, a roguish sense of humor and passion for intellectual combat were hallmarks of his writing, which was prolific. In addition to Vanity Fair, he was a columnist for the online magazine Slate and contributor to Harper's, the Atlantic and a number of British publications. He wrote two dozen books, including highly regarded biographies of George Orwell, Thomas Jefferson and Thomas Paine, and co-wrote or edited at least eight others.
A swashbuckling opinionator, he loved few things better than a good argument — and he knew how to pick one. Once described by the New Yorker as "looking like someone who, with as much dignity as possible, has smoothed his hair and straightened his collar after knocking the helmet off a policeman," he tarred Bill Clinton as a rapist, Mother Teresa as a fraud and Henry Kissinger as a war criminal. He argued in Vanity Fair that women were less funny than men, which stoked the wrath of female comics. "I am programmed by the practice of a lifetime to take," he wrote, "a contrary position."
In his personal life he was no less the "rapscallion iconoclast," as historian Douglas Brinkley once described him. He left his pregnant first wife for another woman. He swore an affidavit during the Monica Lewinsky scandal that put his friend, Clinton aide Sidney Blumenthal, at risk of a perjury charge. Over the years he fell out of friendship with a long list of notables, including novelists Gore Vidal and Saul Bellow, who dismissed Hitchens as a "Fourth Estate playboy thriving on agitation."
After the terrorist strikes of Sept. 11, 2001, he truly became the scourge of the left. Repulsed by what he saw as the left's desire to blame American foreign policy for the attacks, he championed the Bush administration's war on terrorism and resigned his longtime post as Washington columnist for the liberal Nation magazine. His polarizing views brought sarcasm from former allies, one of whom described Hitchens' shift as "the first-ever metamorphosis from a butterfly back into a slug."
"During all this I never quite lost the surreal sense that I had become in some way a pro-government dissident," Hitchens wrote, "and that of all the paradoxes of my little life this might have to register as the most acute one."
Writer Martin Amis said the controversy merely illuminated his friend's "autocontrarian" nature. Hitchens "sees, not only the most difficult position, but the most difficult position for Christopher Hitchens," Amis wrote in the London Guardian in 2011. "Christopher is one of nature's rebels. By which I mean that he has no automatic respect for anybody or anything."
He was born Christopher Eric Hitchens in Portsmouth, England, on April 13, 1949. The elder of two sons, he had a cool relationship with his father, Ernest, a commander in the British Royal Navy, but a warmer one with his mother, Yvonne. She taught him to love books and was determined that he would be the first Hitchens to attend college. "If there is going to be an upper class in this country," Hitchens overheard her telling his father, "then Christopher is going to be in it."
His parents saved enough money to send him to Leys, a boarding school in Cambridge, and then to Balliol College, Oxford, where he studied philosophy, politics and economics and bloomed as a political campaigner. He joined the International Socialists, a faction of the anti-Stalinist left, and charged into the anti-Vietnam War movement. A skillful debater, he discovered that "if you can give a decent speech in public or cut any kind of figure on the podium, then you need never dine or sleep alone." British literary critic Terry Eagleton, who had been a socialist comrade at Oxford, said Hitchens was so nakedly ambitious that he "made Uriah Heep look like Little Nell."
In 1969, Hitchens began writing book reviews for the left-leaning London weekly New Statesman, where he forged important friendships with writers Martin Amis, James Fenton and Ian McEwan. In 1970 he graduated with honors from Balliol and won a grant to travel across the U.S., which left him smitten by his "New World." He returned to England, where he burnished his journalism credentials writing for mainstream and leftist publications. One of his assignments was a New Statesman profile of Margaret Thatcher in which he riled the future prime minister's Conservative Party supporters by calling her sexy. In a subsequent encounter at a party, Thatcher called him a "naughty boy" and swatted his behind.
In 1973, when he was 24 and living in London, his mother committed suicide with her lover, a defrocked vicar, during a trip to Greece.
Years later, he discovered one of her secrets: She was Jewish, which made him Jewish. "My initial reaction, apart from pleasure and interest, was the faint but definite feeling that I had somehow known all along," he wrote in a 1988 essay, "On Not Knowing the Half of It." But he remained anti-religion and anti-Zionist.
With London as his base, Hitchens spent the 1970s covering revolutions and human rights: nail bombers in Belfast, anti-fascists in Portugal, persecuted leftist journalist Jacobo Timerman in Argentina.
While on assignment in Cyprus in 1977, he met Eleni Meleagrou and married her in 1981. He left her when she was expecting their second child and in 1991 married Carol Blue, a freelance journalist.
In addition to Blue, he is survived by their daughter, Antonia; two children from his first marriage, Alexander and Sophia; and a brother, Peter, a conservative columnist for the British paper Daily Mail.
Some Hitchens watchers trace his disillusionment with the left to 1992, when he called for military intervention in Bosnia, but Hitchens said it began later, during the Clinton era. The rupture was complete after the 9/11 strikes in New York and Washington, when Hitchens drew a line between himself and other leading liberals, such as Noam Chomsky.