Van der Sloot told the German news agency RTL that he disposed of Holloway's body in a swamp on the island of Aruba.
Joran van der Sloot made the statements in front of RTL's cameras.
However, the chief prosecutor in Aruba has called the statements "lies and fantasy."
Reports say this confession is similar to the one van der Sloot made two years ago to a Dutch crime reporter, which he later claimed he had made up to impress the reporter..
Holloway was on vacation in May 2005 with about 100 classmates celebrating their graduation from Mountain Brook High School near Birmingham, Alabama.
The high school group had planned to leave Aruba the next day, and Holloway's packed bags and passport were found in her hotel room after she failed to show up for her flight.
Her body has never been found.