Stored at minus 321 degrees

STORED AT MINUS 321 DEGREES: Kaj Rydman, president of Family Cord Blood Services, with one of the firm’s freezer tanks. He says many parents bank cord blood on “blind faith.” (Anne Cusack / LAT / June 19, 2005)

The courier arrived just after midnight with a bag of blood collected from a fresh umbilical cord.

Inside the laboratory at Family Cord Blood Services in Santa Monica, a worker siphoned off red cells, leaving a dilute mixture of stem cells — a personal supply for Olivia Michelle Boyd, born 15 hours earlier in Honolulu.

Her parents, Stephanie and Anthony Boyd, had agreed to pay the company $1,265 to harvest the material and $115 a year to preserve it in a stainless steel tank filled with liquid nitrogen.

Olivia was perfectly healthy. The stem cells were, the sales pitches suggested, biological insurance against disease.

"I'm unsure about the future," Stephanie Boyd said. "I know doing this is the best step."

In the still-experimental field of stem cells, the banking of umbilical cord blood has emerged as its biggest industry, driven by marketing claims that the blood could one day have the potential to cure ailments such as Parkinson's disease, paralysis and diabetes.

But there is little evidence that the promise of cord blood will ever be realized. The blood does indeed contain stem cells, but they are far different from the much-touted embryonic stem cells, which come from newly formed embryos and have the ability to become any tissue type.

That crucial distinction has been largely ignored in the marketing by more than two dozen companies around the world, most of them founded within the last five years. They have brought in hundreds of millions of dollars in harvesting and annual storage fees.

"I think the most exciting thing is that we don't know," said Dr. Charles Sims, a pathologist and co-founder of Family Cord Blood Services. "We can't say there won't be discoveries made."

The current uses of the stored stem cells are limited, and the private banks have little to show for their work so far.

The three largest cord blood businesses in the United States have collected more than 230,000 samples, generating at least $300 million in revenue from anxious parents. Just a few dozen cord blood samples have been used, primarily for children with leukemia who could have been treated with equally effective alternatives.

At Family Cord Blood Services, just one sample has been used out of the more than 9,000 collected over the last eight years. The child died.

"This is purely a commercial business," said Dr. Eliane Gluckman, a French hematologist who performed the world's first successful cord blood transplant in 1988. It is "just for profit and not for benefit."

The European Group on Ethics in Science and New Technologies, which advises the European Union, concluded last year that "the legitimacy of commercial cord blood banks should be questioned as they sell a service, which has [currently] … no real use regarding therapeutic options."

Italy enacted a ban on private banking in 2003 and other European countries have prohibited any company from profiting from cord blood.

The American Academy of Pediatrics also opposes private cord blood storage.

But despite the chorus of objections, the demand for private banking is growing.

Each burst of news articles on the promise of stem cells drives more parents to bank cord blood, if only to ensure that their children aren't deprived of a chance at a cure.

It is "a therapeutic option that not everybody is going to have," said Dr. Robert Hariri, president of LifebankUSA, a Cedar Knolls, N.J., company with more than 20,000 customers.