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Nicollette Sheridan, Katherine Heigl, T.R. Knight

ABC stars fly the coop Well, except for this guy, and no one cares if he comes or goes, right? Not when central characters -- Edie on "Desperate Housewives" and Izzie and George on "Grey's Anatomy" -- are really leaving! (Or are they?) Now if they said "Brothers & Sisters" sibling Kevin Walker, played by the glorious Matthew Rhys, was leaving.... Getty Images / Associated Press / Associated Press