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Ryan Seacrest

Funniest: Ryan Seacrest in 'Knocked Up' Ryan Seacrest’s brief appearance in “Knocked Up” had all the elements of a great cameo: 1. It was unexpected (He’s not a member of the Apatow clan). 2. It wasn’t a stretch (what’s more natural than Seacrest preparing for an interview on "E!"?). 3. It was hilarious (he had the fake nervous breakdown that we all assume he must have, but we never see because no one works harder than Seacrest). In other words, Seacrest up! “Knocked Up.” Charley Gallay / Getty Images
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