Abruptly departed: Leah Remini and Holly Robinson Peete (pictured with Cameron Mathison)
Lasted: One season (2010-2011)
Why they left: Much speculation has been made over the co-hosts' abrupt exits. At first, rumors swirled that fellow "Talk" personality Julie Chen was behind the axings (she's married to CBS executive Leslie Moonves). Later, Remini accused Sharon Osbourne, tweeting, "Sharon thought me and Holly were 'ghetto.' " Although Osbourne denied it.
How it went down on air: Awkwardly, the show avoided Remini and Peete's departures when it returned for a second season in September 2011.
Of course, they weren't the only stars who left before their TV show had given up its soundstage. Here's a look at cast members from other programs who left their roles early and how they were replaced.