- E Street Band (music group), The
- Eads, George
- Eagles (music group), The
- Ealy, Michael
- Earl Brown, W.
- Earle, Justin Townes
- Earle, Steve
- Earth, Wind & Fire (music group)
- Eastman, George
- Eastwood, Clint
- Ebersol, Dick
- Ebersole, Christine
- Ebert, Roger
- Ebouaney, Eriq
- Ebsen, Buddy
- Eccleston, Christopher
- Echevarria, Alexia
- Echeverri, Andrea
- Echikunwoke, Megalyn
- Eckhart, Aaron
- Eckstine, Billy
- Eco, Umberto
- Eddy, Nelson
- Edelstein, Lisa
- Eden's Edge (music group)
- Eden, Barbara
- Eder, Linda
- Edgerton, Joel
- Edson, Richard
- Edward Sharpe and the Magnetic Zeros (music group)
- Edward, John
- Edwards, Anthony
- Edwards, Blake
- Edwards, David "Honeyboy"
- Edwards, Ralph
- Edwards, Richard
- Edwards, Sherman
- Edwards, Stacy
- Edwards, Steve
- Edwards, Vince
- Eels (music group)
- Efron, Zac
- Egan, Susan
- Egerton, Tamsin
- Eggers, Dave
- Egglesfield, Colin
- Egolf, Gretchen
- Egoyan, Atom
- Egypt Central (music group)
- Ehle, Jennifer
- Eichmann, Adolf
- Eigeman, Chris
- Eigenberg, David
- Eikenberry, Jill
- Einhorn, Ira
- Einstein, Bob
- Eisenberg, Hallie Kate
- Eisenberg, Jesse
- Eisenstein, Sergei
- Eisler, Hanns
- Eisley, India
- Ejiofor, Chiwetel
- Ejogo, Carmen
- Ekberg, Anita
- El Khatib, Hanni
- Elba, Idris
- Elbow (music group)
- Eldard, Ron
- Eldredge, Brett
- Electra, Carmen
- Electric Prunes (music group)
- Eleniak, Erika
- Eleventh Dream Day (music group)
- Elfman, Danny
- Elfman, Jenna
- Elfont, Harry
- Elise, Kimberly
- Eliza Doolittle (music group)
- Elizabeth, Shannon
- Elizondo, Hector
- Ellington, Duke
- Elliot, Cass
- Elliott, Alison
- Elliott, Bill
- Elliott, Chris
- Elliott, David James
- Elliott, Dick
- Elliott, Helene
- Elliott, Jack
- Elliott, Missy
- Elliott, Sam
- Elliott, Stephan
- Elliott, Stephen
- Ellis Ross, Tracee
- Ellis, Aunjanue
- Ellis, Dave
- Ellis, Greg
- Ellis, Nelsan
- Ellis, Perry
- Ellison, Harlan
- Elmaleh, Gad
- Elwes, Cary
- EMA
- Embry, Ethan
- Emerson, Jim
- Emerson, Michael
- Emicida (music group)
- Eminem
- Emmerich, Noah
- Emmerich, Roland
- Emond, Linda
- Empire of the Sun (music group)
- Empires
- Enberg, Dick
- Endurance (music group)
- England, Dave
- Englander, Nathan
- English, Corri
- Englund, Robert
- Engvall, Bill
- Eno, Brian
- Enya
- Ephron, Nora
- Epperly, Katelyn
- Epps, Mike
- Epps, Omar
- Epstein, Alvin
- Epstein, Jake
- Erbe, Kathryn
- Erickson, Ethan
- Ermey, R Lee
- Errico, Melissa
- Erskine, Chris
- Erving, Julius
- Erwin, Mike
- Escovedo, Pete
- Esiason, Boomer
- Eskin, Leah
- Esposito, Giancarlo
- Esposito, Jennifer
- Essandoh, Ato
- Esser (music group)
- Essman, Susie
- Estefan, Emilio
- Estefan, Gloria
- Estevez, Emilio
- Estevez, Renee
- Estrada, Erik
- Etheridge, Melissa
- Ettes (music group), The
- Eubanks, Bob
- Eubanks, Kevin
- Eugenides, Jeffrey
- Eurythmics (music group)
- Evancho, Jackie
- Evans, Brian
- Evans, Chris
- Evans, Dale
- Evans, Faith
- Evans, Gene
- Evans, George
- Evans, Janet
- Evans, Lee
- Evans, Linda
- Evans, Paul
- Evans, Richard Paul
- Evans, Robert
- Evans, Sara
- Evans, Shaun
- Evans. Alice
- Eve, Alice
- Everest (music group)
- Everett, Chad
- Everett, Edward
- Everett, Rupert
- Everhart, Angie
- Everlast
- Everly Brothers (music group), The
- Everson, William K
- Example (music group)
- Excision (music group)
- Explosions in the Sky (music group)
- Eyre, Richard