O'Donnell will tape her final show March 20 and the last episode will air at 6 p.m. March 30.
"I thank Rosie from the bottom of my heart for joining me on this journey. She has been an incredible partner, working to deliver the best possible show every single day," Oprah Winfrey said in a release. "As I have learned in the last 15 months, a new network launch is always a challenge and ratings grow over time as you continue to gather an audience. I'm grateful to Rosie and the dedicated Rosie Show team for giving it their all."
"The Rosie Show" launched Oct. 10, 2011, drawing barely a half million viewers. The format of the show, which taped at Harpo Studios in Chicago, was tweaked over the next five months but was unable to improve its ratings.
A Huffington Post report a few weeks ago suggested that O'Donnell was having difficulty getting celebrity guests to travel to Chicago. At least 30 staffers were fired earlier in the year.
O'Donnell put her 12-room, 6,000-square-foot house in Lakeview up for sale for $2.5 million in early March. It went under contract after one day on the market. That led to speculation that she was moving her show to New York, where she lives with her fiance and children.
"I loved working with Oprah in the amazing city of Chicago," O'Donnell said in the release. "I was welcomed with open arms and will never forget the kindness of all I encountered. It was a great year for me. I wish the show was able to attract more viewers, but it did not. So I am headed back to my home in New York, with gratitude. On we go!"