Greg Gayne / Fox
Abruptly departed: Lisa Edelstein
Played: Dr. Lisa Cuddy, the on-and-off love interest of Hugh Laurie's House
Lasted: Seven seasons (2004-2011)
Why she left: The actress announced her own departure in May 2011, saying "after much consideration, I am moving on with a combination of disappointment at leaving behind a character I have loved playing for seven years and excitement of the new opportunities in acting and producing that lie ahead."
How it went down on air: Cuddy and House have lunch to discuss their never-discussed breakup; when he later returns to her house to find she's been set up on a date, he drives his Buick into her dining room. Cuddy tells the cops she wants him arrested if he comes near her, but come fall 2011, it seems like she will be the one who'll stay away.