Fellow senior Juvonte Reddic added 13 points and 14 rebounds and Treveon Graham scored 18 for VCU (24-7, 12-4 Atlantic 10), which finished the season 15-0 at home and has won 20 in a row at the Siegel Center.
Matthew Wright scored 21 to lead the Bonnies (16-14, 6-10), who lost their fourth straight.
St. Bonaventure used a 10-2 run to get within 60-54 with 9:05 to play, but Brandenberg started the game-clinching burst with a jumper from the free-throw line, and Graham followed a turnover with a 3-pointer.
The Bonnies turned the ball over 24 times, leading to 31 points for the Rams.
The Rams will either be the second or third seed in the A-10 tournament in Brooklyn, N.Y., next week.
Brandenberg and Reddic, who will play in the NCAA tournament in all four years of their careers, were removed together by Coach Shaka Smart with 1:10 remaining to rousing cheers from the crowd. It was the 50th consecutive sellout, the fifth-longest streak in the country.
The game was sloppy both ways. The pace was slowed greatly by tight officiating, which saw the Bonnies whistled for 21 fouls and the Rams for 19. ...
Derrick Colter pumped in 21 points to help the Dukes (13-16, 5-11) claim the No. 10 seed in the 13-team Atlantic 10 tournament. Duquesne faces the No. 7 seed on Thursday.
The loss sent No. 12 seed George Mason (11-19, 4-12) into an opening-round game Wednesday against No. 13 Fordham.
The Dukes closed the first half with a 13-2 run, taking a nine-point lead into intermission, then opened the second half by hitting three straight, unanswered 3-pointers.
Sherrod Wright scored 25 points to lead George Mason, with Bryon Allen adding another 17 points. ...
Dayton (22-9, 10-6) took control midway through the first half with a 12-0 run capped by a three-point play from Kyle Davis that made it 24-10 with 4:25 to go before the break. The Flyers took a 34-19 advantage into halftime and never trailed again, finishing the regular season with three wins in a row.
The Spiders (18-13, 8-8) narrowed the gap to single digits on a Terry Allen layup that made it 52-44 with 5:40 left, but got no closer.
Kendall Anthony led Richmond with 20 points and Allen finished with 17. ...
GW (23-7, 11-5), looking to improves its NCAA resume', led cellar-dwelling Fordham 31-29 at intermission.
Branden Frazier led the Rams with 28 points, but Fordham made only 3-of-24 3-point attempts.
NCAA Division III tournament:
All-American senior guard DJ Woodmore scored 28 points to lead Virginia Wesleyan to a 79-74 home win over Wesley, giving the Marlins their third Sweet 16 appearance in the last four years.
VWC's Sedric Nady scored 13 points, though he didn't connect on a field goal until there was 8:19 remaining. He hit a trio of late 3-pointers, including a shot that brought the near-capacity crowd to a roar with a 73-63 lead and 3:46 left.
Wesley, the Capital Athletic Conference regular-season champ, scored six points in a row to make it 77-74 with 1:56 left. Aaron Clark sank two free throws with 16 seconds left for the 79-74 final.
Virginia Wesleyan's next foe will be Mary Washington, which earned its first Sweet 16 trip, rolling past DeSales (Pa.) 77-59 in Ashland.
The Eagles (24-5) controlled the first half for a 38-15 lead and finished the game shooting 46 percent, compared to 28 percent by the Bulldogs.
DeSales, with former William and Mary point guard Scott Coval in his 21st season as coach, had beaten Randolph-Macon on the Yellow Jackets' floor the previous night.
The site and time of the VWC-UMW game will be announced Sunday.
Mount St. Mary's, coached by New Kent graduate Jamion Christian, advanced to the Northeast Conference final by beating host Wagner 77-72 at Staten Island, N.Y., and is just one victory from an NCAA tournament automatic bid.
Sam Prescott and Landstown High graduate Julian Norfleet chipped in with 16 points apiece for the Mountaineers (15-16), who will await top seed Robert Morris in Tuesday's championship game in Coraopolis, Pa., near Pittsburgh. Gregory Graves contributed 12 points and seven rebounds off the bench in the win.
The Seahawks (19-12), who never led in the second half, saw their nine-game win streak end despite a game-high 26 points from Kenneth Ortiz.
Big South tournament:
Josh Cameron scored 17 points as tournament host Coastal Carolina ousted VMI 66-62 in a semifinal in Conway, S.C.
Warren Gillis added 12 points for the Chanticleers (20-12), while Badou Diagne had 11 points, 11 boards and four blocks, Tristian Curtis grabbed 13 rebounds and Elijah Wilson had 11 points.
Virginia Beach's D.J. Covington registered a double-double for VMI (19-12) with 18 points and 12 rebounds. Rodney Glasgow and Q.J. Peterson contributed 14 points apiece, with Glasgow also accounting for five of the Keydets' 10 steals.
VMI trailed by one point before Gillis made a clutch jumper with 24 seconds left. After Peterson's potentially tying 3-pointer missed, Cameron put the game out of reach with a free throw.
The Chanticleers finished with a 48-35 edge in total rebounds and advanced despite committing 16 turnovers compared to only nine by VMI.
The Chanticleers (19-12) advanced to an all-South Carolina championship game against Winthrop (20-12), which edged UNC Asheville 80-79. The champion will gain an NCAA automatic bid, though the winner will be a candidate for the First Four in Dayton, Ohio.
Winthrop's Keon Johnson scored the last five points as his team knocked off a higher seed for the second day in a row and made the final for the first time since 2010.
Johnson finished with 16 points and hit a pair of jumpers with less than 2 minutes to play, giving the Eagles an 80-77 lead. Both scores came after Asheville misses.
Twenty of Winthrop's 26 rebounds were off the defensive glass.
The Bulldogs (17-15) missed a driving layup and a putback in the final 10 seconds.
Zach Stahl added 19 points and 12 rebounds for the Huskies, and David Walker had 18 points for Northeastern.
Chris Fouch, a sixth-year college player, scored 30 points for the Dragons, who committed 33 fouls -- many during the late stages in an effort to stop the clock and catch up. Northeastern was 32-of-44 at the free-throw line, while Drexel was 14-of-21.
The Huskies earned a spot in Sunday's 2:30 p.m. semifinal against top-seeded Delaware, which trailed throughout the first half -- and by as many as nine points -- but gradually overcame No. 8 Hofstra 87-76.
Davon Usher led all scorers with 28 points. Jarvis Threatt added 22, Devon Saddler 15 and Kyle Anderson 12 for the Blue Hens (23-9).
Zeke Upshaw scored 23 points for the Pride (10-23), which was coming off a first-round win over UNC Wilmington on Friday night. Dion Nesmith contributed 16 points, and reserve Stephen Nwaukoni recorded 13 points and 15 rebounds.
The Blue Hens shot 64 percent from the field in the second half and were 80 percent (20-of-25) on free throws in the last 20 minutes. Threatt scored 18 of his 22 points in the second half while going 6-of-7 from the floor.
Patriot League tournament:
D.J. Irving scored 20 points and Maurice Watson Jr. had 17 assists as host Boston University defeated Army 91-70 in a Patriot League semifinal.
Malik Thomas supplied 15 points and seven rebounds and Dom Morris contributed 16 points for the top-seeded Terriers (24-9).
BU, which won its fourth game in a row, will play at home in Wednesday's championship game against American, which beat Holy Cross 57-46 in Washington.
Kyle Wilson paced Army (15-16) with 22 points and Dylan Cox had 12 points and five boards, but the Black Knights' two-game win streak ended.
For American, Jesse Reed scored 18 points for the second-seeded Eagles.
Anthony Thompson (10 points) scored eight of Holy Cross' first 12 points in the second half to boost the Crusaders' advantage to a game-high 10, but American went to a 2-3 zone. Holy Cross became flustered, going scoreless for nearly seven minutes and ending the NCAA tournament hopes of a team coached by Hampton native Milan Brown.
Apprentice guard Johnnie Ferebee made the all-tournament team in the U.S. Collegiate Athletic Association national championships in Uniontown, Pa., which Washington Adventist won.